Exosomal MiR-1290 Promotes Angiogenesis of Hepatocellular Carcinoma via Targeting SMEK1

Hepatocellular carcinoma (HCC), the most common primary liver cancer, relies on formation of new blood vessel for growth and frequent intrahepatic extrahepatic metastasis. Therefore, it is important to explore underlying molecular mechanisms tumor angiogenesis HCC. Recently, microRNAs have been shown modulate angiogenic processes by modulating expression critical factors. However, potential roles tumor-derived exosomal in regulating remain be elucidated. In this study, our miRNome sequencing demonstrated that miR-1290 was overexpressed HCC patient serum-derived exosomes, we found delivery into human endothelial cells enhanced their ability. Our results further revealed SMEK1 a direct target cells. MiR-1290 exerted its proangiogenic function, at least part, alleviating inhibition VEGFR2 phosphorylation done SMEK1. Collectively, findings provide evidence promotes via secretion, implicating role as therapeutic